Endocrine Abstracts

A 44 year old man attended our endoscopy unit for gastroscopy to further investigate ongoing epigastric pain. He was incidentally found to be very hypertensive so gastroscopy was cancelled. Hypertension was treated. He had past medical history of hypertension and Gout. Routein blood tests showed renal impairment with significantly raised calcium 3.19 mmol/l. Hypercalcemia was treated with iv bisphosphonates. MEN 2a, was considered as a unifying diagnosis for high calcium and h...

We report a 38 years old male who was referred to the endocrine clinic with 3 months history lethargy, lack of libido and reduced shaving frequency. He was previously fit and well with no past medical history however he and his wife has been trying for pregnancy for 2 years. He didn’t smoke, has no history of opioids use and drink 10 units of alcohol a week. His investigation showed panhypopiturism with profound low serum testosterone of <0.5 nmol/l (8.33–30.19),...

Addisons disease is a rare but potentially life threatening endocrine disorder. It is well-known for disguising as a variety of presentations before diagnosis. Here we present a case report of Addison’s disease presenting with very severe hyponatraemia. A 35 year old lady was admitted with lethargy, low mood, weight loss and feeling generally unwell for the last 3 months. Six weeks prior to her admission, her GP arranged some routine investigations including U&E which...

A 34 year old male, previously healthy nightclub doorman presented with 2 years of reduced libido, fatigue, hot flushes and reduced beard growth. He had fathered three healthy children. He admitted to previous use of veterinary anabolic steroids up until 2 years ago. He had normal secondary sexual characteristics, no features of pituitary hypersecretion, normal visual fields but reduced testicular volumes (8 ml).Biochemical investigation showed growth ho...

Untreated hypothyroidism in pregnancy is associated with severe neurodevelopmental delay. Based on rodent experiments, maternal T3 is said not cross the placenta and to have little if any role in fetal brain development.Case report: A 36-year-old female with known hypothyroidism treated only with liothyronine (T3) 20 μg TDS. attended the antenatal clinic. It was suggested that she changed to treatment with levothyroxine (T4) or a combination of T3 a...

Introduction: Thyroid hormones are critical for early brain development, somatic growth, and bone and pubertal maturation. Primary hypothyroidism is a well-known cause of poor linear growth in children. This case highlights role of thyroid hormone replacement to improve final height in the setting of profound hypothyroidism.Case: We report the case of 16 years old Caucasian girl initially evaluated for primary amenorrhea and delayed growth of 139 cm putt...

Introduction: Dual oxidase 2(DUOX2) is NADPH oxidase complex at the apical membrane of the thyroid follicular cells which produce H2O2 required for thyroid hormone synthesis. DUOX2 gene mutation is a well known cause of congenital hypothyroidism (CH), the phenotype depends on the type of mutation and environmental factors.Case: We present a case of 29 years old female delivered a male baby with large neonatal goitre and severe CH who was started immediat...

MEN2a is a rare genetic endocrine disorder associated with mutation of RET oncogene on chromosome 10. It involves lesions in thyroid, parathyroid and adrenal glands. Medullary thyroid carcinoma is the pathological hallmark and usually the first presentation of this syndrome.Clinical case: A 64-year-old lady with previous history of hypertension, IHD, and hypercholesterolemia was referred to Endocrine clinic after she was incidentally found to have high c...

Introduction: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder of young women and depending on the diagnostic criteria, it affects 6% to 20% of reproductive aged women. PCOS is also the most common cause of hyperandrogenism in young women with the theca cells of the ovary being the source of androgen excess. PCOS is rarely associated with severe hyperandrogenaemia and atypical features such as rapid progression, presence of virilization or very high Testo...

Introduction: Reproductive health is closely related with nutritional status of a country. Nutritional problems are different between developed and developing countries. In the context of Bangladesh there is no recent assessment. This study aims to assess the nutritional status and reproductive morbidity among women in Dhaka city.Description of methods: A cross-sectional study was performed in 400 women, aged 15–40 years, in Dhaka city. Sample was s...